Powel H. Brown, M.D., Ph.D.

Professor of Medicine, Baylor College of Medicine
Associate Director of Cancer Prevention, Dan L. Duncan Cancer Center
Director of Cancer Prevention and Population Sciences Program,
      Dan L. Duncan Cancer Center
Associate Director of Research, Breast Center

Powel H. Brown, M.D., Ph.D.Phone: 713-798-1609
Fax: 713-798-1642
Email: pbrown@breastcenter.tmc.edu

Funding
Publications
PCR Core
Research Lab

Departmental Appointments:
Department of Medicine, Division of Medical Oncology, web site
Department of Molecular and Cellular Biology, web site

Education:
B.S. - University of North Carolina, Chapel Hill
M.D. - New York University
Ph.D. - New York University

Certifications:
Texas Medical Licensure
National Boards, Parts 1, II and III
Diplomate, American Board of Internal Medicine
Diplomate, American Board of Internal Medicine - Subspecialty in Medical Oncology
Diplomate, National Board of Medical Examiners

Honors and Awards:
1978 - National Science Foundation Research Fellowship
1979 - Kenan Chemistry Award for outstanding research
1979 - Phi Beta Kappa
1979-1985 - NIH Medical Scientist Training Fellowship
1984 - Alpha Omega Alpha National Medical Honorary Society
1985 - Bertram Gesner Memorial Award for excellence in Immunology Research
1988 - American College of Physicians Clinical Vignette winner
1992 - Public Health Service Outstanding Achievement Medal
1993 - Public Health Service Citation Award
1996 - Career Development Award, SPORE in Breast Cancer
1997 - V Foundation Scholar
2007 - Dan L. Duncan Endowed Professorship

Fellowships:
National Cancer Institute - Medical Oncology Fellowship

Professional Associations and Affiliations:
Cancer Genetics Network
National Surgical Breast and Bowel Adjuvant Project Group
Southwest Oncology Group
Texas Cancer Genetics Consortium
American Association for Cancer Research
American Association for the Advancement of Science
American Society of Clinical Oncology

Special Procedures and Interests:
Diagnosis, prevention and treatment of breast cancer.
Cancer Genetics

Brief Description of Research:
Dr. Brown's primary research interest is in cancer prevention, and the identification and testing of cancer preventive agents. He developed innovative methods to interfere with the AP-1 signaling system in breast cancer cell proliferation and progression, applying these AP-1 inhibitors to in vitro and in vivo carcinogenesis models. Dr. Brown has also shown that retiniods, derivatives of Vitamin A, and signal transduction inhibitors prevent the development of breast cancer. These studies have led to the opening of a clinical trial testing whether receptor-selective retiniods suppress breast cell growth in women at high risk of breast cancer. His primary clinical interest is assessing cancer risk and reducing cancer risk using cancer preventive agents. Dr. Brown directs the Cancer Prevention Section of the Smith Breast Center as well as the Baylor - Methodist site of the STAR Trial. This particular aspect of the clinic allows the physician to counsel the patients on their risk of breast cancer.