Jenny C. Chang, M.D. - Publications

Selected publications:

A Makris, TJ Powles, SE Ashley, J Chang, et al. A reduction in the requirement for mastectomy in a randomized trial of neoadjuvant chemoendocrine therapy in primary breast cancer. Annals of Oncology 1998;9:1179-1184. [Abstract]

J Chang, TJ Powles, SE Ashley. Variation in endometrial thickening in women with amenorrhea on tamoxifen. Breast Cancer Res and Treat 1998;48:81-85. [PDF]

J Chang. A review of breast cancer chemoprevention. Biomedicine and Pharmacotherapy 1998;52:133-136. [PDF]

J Chang, HL Lim, J Wong. Primary medical therapy for breast cancer. Medical Progress 1998;25(10):23-26.

TJ Powles, TH Bourne, J Chang, et al. The effects of norethisterone on endometrial abnormalities identified by transvaginal ultrasound screening of healthy postmenopausal women on tamoxifen or placebo. British J Cancer 1998;78(2):272-275. [Abstract]

TJ Powles, R Eeles, SE Ashley, J Chang, et al. Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital Tamoxifen Chemoprevention trial. Lancet 1998;352:98-101. [PDF]

J Chang, TJ Powles, DC Allred, et al. Biologic markers predict clinical outcome from systemic therapy for primary operable breast cancer. J Clin Oncol 1999;17:3058-3063. [PDF]

M Dowsett, C Archer, L Assershon, RK Gregory, PA Ellis J Salter, J Chang, et al. Clinical studies of apoptosis and proliferation in breast cancer. Endocrine-related Cancer 1999;6:1-4. [PDF]

J Chang, WT Yang, HF Choo. Mammography in Asian patients with BRCA1 mutations. Lancet 1999;353:2070-2071. [PDF]

L Assersohn, TJ Powles, S Ashley, AG Nash, AJ Neal, N. Sacks, J Chang, U Querci della Rovere, N Naziri. Local relapse in primary breast cancer patients with unexcised positive surgical margins after lumpectomy, radiotherapy and chemoendocrine therapy. Annals of Oncology 1999;10(12):1451-1455. [Abstract]

WT Yang, J Chang, C Metreweli. Patients with breast cancer: differences in color Doppler flow and gray-scale US features of benign and malignant axillary lymph nodes. Radiology 2000;215(2):568-573. [PDF]

J Chang, TJ Powles, DC Allred, SE Ashley, A Makris, RK Gregory, CK Osborne, M Dowsett. Prediction of clinical outcome from primary tamoxifen by expression of biologic markers in breast cancer patients. Clin Cancer Res 2000;6:616-621. [PDF]

RK Gregory, TJ Powles, J Salter, JC Chang, S Ashley, M Dowsett. Prognostic relevance of cerbB2 expression following neoadjuvant chemotherapy in patients in a randomised trial of neoadjuvant versus adjuvant chemoendocrine therapy. Breast Cancer Res Treat 2000;59(2):171-175. [PDF]

JH Sng, J Chang, F Feroze, et al. Prevalence of BRCA1 mutations in Chinese women with early onset and familial breast cancer. British J Cancer 2000 Feb;82(3):538-542. [PDF]

J Chang, M Ormerod, TJ Powles, DC Allred, SE Ashley, M Dowsett. Apoptosis and proliferation as predictors of chemotherapy response in patients with breast carcinoma. Cancer 2000;89(11):2145-2152. [PDF]

WT Yang, C Metrewelli, J Chang. Benign and malignant breast masses axillary lymph nodes: evaluation with enhanced color Doppler angiography ultrasound. Radiology 2001; 220: 795-802. [PDF]

J Chang, TJ Powles, DC Allred, et al. Biologic markers in prediction of clinical response from systemic therapy for primary operable breast cancer. J Clin Oncol 2000; 17 (10): 1601-1602 (letter).

S-E Lim, J E-L Wong, J Chang, A-B Ong, C Chua, K-C Lun, WTL Tan. Breast cancer in Singapore: a clinicopathologic analysis of 848 Asian women with invasive breast cancer from a single institution. Cancer 2002 (submitted).

J Chang, N Rahman, SG Hilsenbeck, J Wong, GC Ragu. Pathologic features and BRCA1 mutation screening in premenopausal breast cancer patients. Clinical Cancer Research 2001; 7:1739-1742. [PDF]

J Chang, RM Elledge. Clinical management of women with genomic BRCA 1 and 2 mutations. Breast Cancer Res Treat 69: 101-113, 2001. [PDF]

Yee-Lu Tham, Mario S Verani, J Chang. Reversible and irreversible cardiac. Dysfunction associated with trastuzumab in breast center. Breast Cancer Res Treat 2002; 74:131-134.

O’Shaughnessy JA, Ljung BM, J Chang et al. Ductal lavage and the clinical management of women at high risk for breast carcinoma: a commentary. Cancer 2002; 94(2):292-8.

WT Yang, GMK Tse, PKW Lam, C Metreweli, J Chang. Correlation between color power Doppler sonographic measurement of breast tumor vasculature and immunohistochemical analysis of microvessel density for the quantitation of angiogenesis. J Ultrasound Med 2002; 21:1227-1235. [PDF]

J Chang. Study design: Sequential biopsy data from women undergoing neoadjuvant therapy with trastuzumab followed by tratuzumab/docetaxel. HER2 in Oncology 2002;3:5-8

J Chang, GM Clark, DC Allred, et al. Survival of patients with metastatic breast cancer: importance of prognostic markers of the primary tumor. Cancer 2003; 97:545-553. [PDF]

JC Chang, EC Wooten, A Tsimelzon, SG Hilsenbeck, MC Gutierrez, R Elledge, S Mohsin, CK Osborne, GC Chamness, DC Allred, P O’Connell. Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer. The Lancet 2003;362:362-369. [PDF]

J Chang, EC Wooten, A Tsimelzon, et al. Gene expression profiling for the prediction of the therapeutic response to docetaxel. The Lancet 2003: 362:340 (commentary). [PDF]

JC Chang. Gene expression patterns for docetaxel sensitivity and resistance in patients with locally advanced breast cancer. Cancer Conference Highlights 2003;7:8-10.

JC Chang. Docetaxel resistance identified in gene expression patterns. (Commentary). Oncology Times August 10, 2003.

JC Chang. Chipping away at cancer in vivo, in situ (Commentary). Bio.It World 2:40, 2003.

JC Chang. Expression patterns for docetaxel sensitivity and resistance. The American Journal of Oncology Review 2:656-659, 2003.

AE Van Pelt, S Mohsin, RM Elledge, SG Hilsenbeck, MC Gutierrez, A Lucci Jr., M Kalidas, T Granchi, BG Scott, DC Allred, JC Chang. Neoadjuvant trastuzumab and docetaxel in locally advanced breast cancer patients: preliminary results. Clinical Breast Cancer 4: 348-353, Dec 2003. [Abstract]

JC Chang. Clinical management of anemia in cancer patients. Physicians’ Education Resource Cancer Conference Highlights, 9:8-10, 2003.

JC Chang. Neoadjuvant Docetaxel for operable breast cancer induces a high pathologic response and breast conservation rate (Commentary) Breast Diseases: A Year Book Quarterly 15: 2004

L Assersohn, Salter J, Powles TJ, R A’Hern, A Makris, RK Gregory, J Chang. Studies on the potential utility of Ki67 as a predictive molecular marker of clinical response in primary breast cancer. Breast Cancer Research and Treatment 2003:82:113-123. [PDF]

J Chang. Neoadjuvant trastuzumab/docetaxel in inflammatory breast cancer. Physician’s Education Resource 2004; 3(8): 1-8

SAW Fuqua, JC Chang, SG Hilsenbeck. Genomic approaches to understanding and treating breast cancer. Breast Disease 2004; 19: 35-46. [Abstract]

JC Chang. Neoadjuvant Herceptin and docetaxel in locally advanced breast cancer. Physician’s Education Resource 2004;3(6):1-6

K Sam, JC Chang. A case report of response to gefitinib and tamoxifen in a patient with estrogen receptor positive and HER-2 overexpressing locally advanced breast cancer. Physician’s Education Resource 2004; 3(10):1-6

S Mohsin, H Weiss, MC Gutierrez, G Chamness, R Schiff, MP DiGiovanna, CX Wang, SG Hilsenbeck, CK Osborne, DC Allred, R Elledge, JC Chang. Neoadjuvant trastuzumab induces apoptosis in primary breast cancers. Journal of Clinical Oncology 2005;23(11):2460-2468/ [PDF]

JC Chang, EC Wooten, A Tsimelzon, SG Hilsenbeck, MC Gutierrez, YL Tham, M Kalidas, R Elledge, S Mohsin, CK Osborne, GC Chamness, DC Allred, MT Lewis, H Wong, P O’Connel. Patterns of resistance and incomplete response to decetaxel (Taxotere) by gene expression profiling in breast cancer patients. Journal of Clinical Oncology 2005; 23:1169-1177 [PDF]

JC Chang, SG Hilsenbeck, SAW Fuqua. Genomic approaches in the management and treatment of breast cancer. British J Cancer 2005;92:618-24. [PDF]

JC Chang, SAW Fuqua, SG Hilsenbeck. The promise of microarrays in the management and treatment of breast cancer. Breast Cancer Res. 2005;7(3):100-4. Epub 2005 Apr 1. [PDF]

Y Cui, SG Hilsenbeck, JC Chang, SAW Fuqua. Heat shock protein Hsp27 overexpression sensitizes breast cancer cells to paclitaxel. Submitted to Cancer Research 2004.

KM Dobrzycka, K Kang, S Jiang, R Meyer, R Pulivarthi, V Bardou, A Tsimelson, J Chang, CK Osborne, AV Lee, S Oesterreich. The Scaffold Attachment Factor SAFB1-A Novel Player in Senescence and Drug Resistance. Submitted to Cancer Cell 2005

S Cleator, A Tsimelzon, A Ashworth, M Dowsett, T Dexter, T Powles, S Hilsenbeck, H Wong, CK Osborne, P O’Connell, JC Chang.Gene expression patterns for doxorubicin (Adriamycin) and cyclophosphamide (Cytoxan) (AC) response and resistance. Submitted to Breast Cancer Research and Treatment 2005 (in press)

YL Tham, LF Gomez, S Mohsin, MC Gutierrez, H Weiss, SG Hilsenbeck, RM Elledge, GC Chamness, CK Osborne, DC Allred, JC Chang. Clinical response to neoadjuvant docetaxel predicts improved outcome in patients with large locally advanced breast cancers. Submitted to Clinical Cancer Research
Publications, Books/Chapters, Abstracts

Books/Chapters:

J Chang, TJ Powles. Chemoprevention of breast cancer. In: G Bonadonna, GN Hortobagyi, AM Gianni (eds). Textbook of medical oncology of breast cancer. Martin Dunitz Publishers 1997;21:335-341.

J Chang, TJ Powles. The prevention of breast cancer: recent developments and future progress. In: Morgan M, Warren R, Querci della Rovere G (eds). Breast screening and the management of early breast cancer. Graffham Press, Edinburgh. 1998;265-269.

M Dowsett, IE Smith, TJ Powles, J Salter, PA Ellis, SRD Johnson, A Markers, P Mainwaring, RK Gregory, J Chang and L Assersohn. Biologic Studies in Primary Medical Therapy of Breast Cancer: The Royal Marsden Hospital Experience. European School of Oncology Scientific Updates. 1999;4:113-125.

J Chang, RM Elledge, CK Osborne. Receptors – their prognostic and predictive value. In: Seminars in Breast Disease: Radiologic, Pathologic, and Surgical Considerations. 2000; 3(2):62-69.

J Chang, RM Elledge. Pharmacology, biology and clinical use of triphenylethylenes. In: Robertson JER, Michaelson RI, and Hayes D(eds). Endocrine Therapy of Breast Cancer. 2000 (in press)

J Chang, CK Osborne. Selective estrogen receptor modulators and breast cancer prevention. In: Manni A (ed). Selective Estrogen Receptor Modulators Research and Clinical Applications. 2001; 16: 267-278.

J Chang. Sequential biopsy data from women undergoing neoadjuvant therapy with trastuzumab followed by trastuzumab / docetaxel combination. In: Journal Biological Therapy of Breast Cancer. 2002: 3: 5-8.

J Chang, RM Elledge. Pharmacology, biology, and clinical use of triphenylethylenes. In: Endocrine Therapy of Breast Cancer. 2002: 33-44.
Publications, Books/Chapters, Abstracts

Abstracts:

J Chang, TJ Powles, DC Allred, et al. Predictive molecular markers for clinical outcome following primary chemotherapy for operable breast cancer. Proc Am Soc Clin Onc 1998;17:100.

J Chang, JH Sng, J Wong. Germline BRCA1 mutation in young onset breast cancer in Singaporean women. Eur J Cancer (suppl) 1998.

J Chang, JH Sng, J Wong. Germline BRCA1 mutations in Chinese women with young onset breast cancer. Breast Cancer Res and Treat (suppl) 1998;50:297.

L Assersohn, TJ Powles, M Dowsett, J Chang, M Makris, P Trott. Changes in Mib1 expression relate to response in patients receiving primary medical therapy for breast cancer. Breast Cancer Res and Treat (suppl) 1998;50:239.

J Chang, TJ Powles, M Ormerod, et al. Induction of apoptosis and decrease in proliferation predict response to systemic chemotherapy. Proc Am Soc Clin Onco 1999;18:609.

J Chang, P O’Connell, S. Hilsenbeck. Feasibility of measuring gene expression using core biopsies of human primary breast cancers and cDNA microarray technology. Breast Cancer Res and Treat (suppl) 2000.

J Chang, G Clark, S Mohsin, DC Allred, RM Elledge, Tissue arrays for the molecular profiling of inflammatory breast cancers. Breast Cancer Res and Treat (suppl) 2000.

J Chang, GM Clark, DC Allred, CK Osborne, RM Elledge. Survival of metastatic breast cancer patients: Importance of initial prognostic markers in 654 patients. Proc Am Soc Clin Oncol 2001; 20: 43 (Abstr 168), 2001.

J Chang, GM Clark, S Mohsin, DC Allred, RM Elledge. Tissue arrays for the molecular profiling of inflammatory breast cancers (IBC). 23rd Annual San Antonio Breast Cancer Symposium, San Antonio, TX (Abstr 129), 12/2000.

EC Wooten, J Chang, SG Hilsenbeck. Genetic markers of response to neoadjuvant therapy: array-based gene expression profiling from serial core biopsies. 24th Annual San Antonio Breast Cancer Symposium, San Antonio, TX (Abstr 236), 12/2001.

SE Lim, J Wong, J Chang. Clinical features and survival analysis of 848 Asian women with invasive breast cancer: results from a single institution in Singapore. 24th Annual San Antonio Breast Cancer Symposium, San Antonio, TX (Abstr 417), 12/2001.

EC Wooten, J Chang, SG Hilsenbeck, A Tsimelzon, S Moshin, P O’Connell. Gene expression profiles from breast cancer core biopsies predict therapeutic response. Proceedings of the American Association for Cancer Research: 43: 450, 3/2002.

J Chang, EC Wooten, RM Elledge, S Hilsenbeck, A Tsimelzon, S Mohsin, P O’Connell. Gene expression profiles for docetaxel chemosensitivity. ASCO 38th Annual Meeting. (Abstr 1700), 5/2002.

JC Chang, E Wooten, A Tsimelzon, SG Hilsenbeck, MC Gutierrez, S Mohsin, R Elledge, P O’Connell. Gene expression for docetaxel chemosensitivity. Era of Hope, Department of Defense Breast Cancer Research Program Meeting, 9/2002.

Wooten EC, Hilsenbeck SG, Tsimelzon A, Mohsin S, Gutierrez C, Chang J, O’Connell P. Breast cancer gene expression profiles predict response to neoadjuvant taxotere. Breast Cancer Research and Treatment 76:S65, 2002.

Van Pelt AE, Elledge RM, Allred DC, Mohsin SK, Guiterrez MC, Chang J. Phase II study of neoadjuvant trastuzumab plus docetaxel for locally advanced and metastatic breast cancer that overexpresses HER2/neu: a preliminary report. Breast Cancer Research and Treatment 76:S114, 2002.
Publications, Books/Chapters, Abstracts