Michael T. Lewis, Ph.D. - Publications

Selected publications from the past 5 years:

Li. X., Lewis M.T., Huang J., Gutierrez C., Osborne C.K., Wu M., Hilsenbeck S.G., Pavlick A., Chamness G., Wong H., Rosen J., and Chang J.C. (2008) “Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.” J. Natl. Cancer Inst. 2008 May 7;100(9):672-9. Epub 2008 Apr 29. [PDF]

Zhang X., Harrington N., Moraes R., Wu M., Hilsenbeck S., Lewis M.T. (2008) “Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo).” Breast Cancer Research and Treatment (In press)

Kim H.J., Litzenburger B.C., Cui X., Delgado D.A., Grabiner B.C., Lin X., Lewis M.T., Gottardis M.M., Wong T.W., Attar R.M., Carboni J., Lee A.V. (2007) “Constitutively Active IGF-IR Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells, and is Accompanied by an Epithelial to Mesenchymal Transition Mediated by NF-kappaβ and Snail.” Mol. Cell. Biol. 2007 Feb 12 [PDF]

Moraes, R.C., Zhang, X., Harrington, N., Fung, J.Y., Wu, M.F., Hilsenbeck, S.G., Allred, D.C., and Lewis, M.T. (2007).,“Constitutive Activation of Smoothened (Smo) in Mammary Glands of Transgenic Mice Leads to Increased Proliferation, Altered Differentiation, and Ductal Dysplasia.” Development 134 (6): 1231-42. [PDF]

Du, Z., Podsypanina, K., Huang, S., McGrath, A., Toneff, M.J., Bogoslovskaia, E., Zhang, X., Moraes, R.C., Fluck, M., Allred, D.C. Lewis, M.T., Varmus, H.E., and Li, Y. (2006) “Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models” Proc. Natl. Acad. Sci. 103:17396-401 [PDF]

Chang J.C., Wooten E.C., Tsimelzon A., Hilsenbeck S.G., Gutierrez M.C., Tham Y.L., Kalidas M., Elledge R., Mohsin S., Osborne C.K., Chamness G.C., Allred D.C., Lewis M.T., Wong H., O’Connel P. (2005) Patterns of resistance and incomplete response to docetaxel (Taxotere) by gene expression profiling in breast cancer patients. Journal of Clinical Oncology 23(6):1169-77 [PDF]

Lewis, M.T., and Veltmart, J.M. (2004) Next stop, the twilight zone: hedgehog network regulation of mammary gland development. J. Mammary Gland Biol. Neoplasia 9:165-181. [PDF]

Salomon, D.S. and Lewis, M.T. (2004) Embryogenesis and Oncogenesis: Dr. Jekyll and Mr. Hyde. J Mammary Gland Biol Neoplasia. 9:105-7. [PDF]

Lewis, M.T. (2001) Hedgehog signaling in mammary gland development. J. Mammary Gland Biol. Neoplasia 6:53-66 [PDF]

Lewis, M.T., Ross, S., Strickland, P.A., Sugnet, C., Jimenez, E., Hui, C-c. and Daniel, C.W. (2001) The Gli2 transcription factor is required for normal mouse mammary gland development. Dev. Biol. 238:133-144 [PDF]

Lewis, M.T. (2000) Homeobox genes in mammary gland development and neoplasia. Breast Cancer Research 2: 158-169 [PDF]

Nguyen, D., Beeman, N., Lewis, M.T., Schaack, J. and Neville, M.C. (2000) Intraductal injection into the mouse mammary gland. Methods in Mammary Gland Biology and Breast Cancer Research. M.M. Ip and B.B. Asch (eds.) Kluwer Academic/Plenum Publishers, New York. 259-270

Lewis, M.T., Ross, S., Strickland, P.A., Sugnet, C., Jimenez, E. Scott, M.P. and Daniel, C.W. (1999) Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1 (Ptc1). Development 126:5181-5193 [PDF]

Lewis, M.T., Ross, S., Strickland, P.A., Snyder, C.J. and Daniel, C.W. (1999) Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. Cell Tissue Res. 296:549-554 [PDF]

Lewis, M.T. and Feldman, J.F. (1998) Genetic mapping of the band (bd) locus of Neurospora crassa. Fungal Genet. Newsl. 45:21.

Lewis, M.T., Morgan, L.W., and Feldman, J.F. (1997) Analysis of frequency (frq) clock gene homologs: evidence for a helix-turn-helix transcription factor. Mol. Gen. Genet. 253:401-414 [Abstract]

Lewis, M.T. and Feldman, J.F. (1996) Evolution of the frequency (frq) clock locus in fungi. Mol. Biol. Evol. 13:1233-1241 [PDF]

Lewis, M.T., and Feldman, J.F. (1993) The putative frequency (frq) clock protein of Neurospora crassa contains sequence elements that suggest a nuclear transcriptional regulatory role. Protein Seq. Data Anal. 5: 315-323

Ron, D., Zannini, M., Lewis, M.T., Wickner, R.B., Hunt, L.T., Graziani, G., Tronick, S.R., Aaronson, S.A., and Eva, A. (1991) A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr. The New Biologist 3: 372-379

Lewis, M.T., Hunt, L.T., and Barker, W.C. (1989) Striking sequence similarity among sialic acid-binding lectin, pancreatic ribonucleases, and angiogenin: possible structural and functional relationships. Protein Seq. Data Anal. 2: 101-105 [Abstract]

Research Articles, Data Collections

Data Collections:

Protein Sequence Database. Barker, W.C., Hunt, L.T., George, D.G., Yeh, L.S. Chen, H.R., Blomquist M.C., Seibel-Ross, E.I., Elzanowski, A., Bair, J.K., Lewis, M.T., Marzec, C.R., Davalos, D.P. and Ledley, R.S. National Biomedical Research Foundation, Washington, D.C. (Updated quarterly) (1986-1989).

Research Articles, Data Collections