Powel H. Brown, M.D., Ph.D. - Funding
Ongoing and Completed Projects in the last 3 years
Title: Molecular Mechanism by which Retinoids Prevent Breast
Cancer
Agency: NIH/NCI R01 CA78480 (Brown)
Role: PI
Period: 4/1/04-3/31/09
The major goal of this project is to detect the mechanism by which RXR-selective
retinoids prevent breast cancer. This is the continuing extension of the
preceding grant.
Title: Prevention of ER-Negative Breast Cancer: Identification
of Biomarkers Associated with Successful Chemoprevention
Agency: NIH/NCI R01 CA10121 (Brown)
Role: PI
Period: 05/01/03 – 04/30/08
The goal of this project is to identify biomarkers associated with successful
chemoprevention of breast cancer using SAGE and proteomic techniques mouse
models of ER-negative breast cancer.
Title: U-19 Program Project Chemoprevention of Breast and Ovarian
Cancer
Agency: NIH/NCI CA98012 (Brown, Principal Investigator of Program and of
Project #3)
Role: PI
Period: 1999-2006
The major goal of Project 3 is to identify promising markers regulated
by retinoids in human mammary and ovarian epithelial cells using cDNA microarrays
(PI: Brown).
Title: Breast SPORE: Translational Research in Breast Cancer
Project 3, “Prevention of Breast Cancer Using Signal Transduction
Inhibitors”
Agency: NIH P50 CA58183 (overall SPORE PI: Osborne; Project 3 PI: Brown)
Role: PI
Period: 8/1/02-7/31/07
The major goal of this project is to investigate the mechanisms by which
tyrosine kinase inhibitors prevent the development of breast cancer in
animals and humans.
Title: Prevention Member of the NSABP
Agency: NIH/NCI U10 CA37377 (Wolmark)
Role: Site PI
Period: 6/1/01-5/31/06
The major goal of this study is to conduct clinical cancer prevention trials
through the NSABP cooperative group, including the “STAR Breast Cancer
Prevention Trial,” and Phase I and II breast cancer prevention trials.
Title: Neoadjuvant Trial of GW572016 for the Treatment of Women
with DCIS Breast Cancer
Agency: Breast Cancer Research Foundation (Brown)
Role: PI
Period: 2004 – 2005
The goal of this project is to conduct a clinical trial testing the dual
kinase inhibitor for the treatment of women with DCIS Breast Cancer
Title: Prevention of Breast Cancer Using Lox Inhibitors
Agency: AstraZeneca Alliance Grant (Brown)
Role: PI
Period: 2003 – 2005
The goal of this project is to investigate the cancer preventive activity
of LOX inhibitors in in-vitro and in-vivo assays.