Powel H. Brown, M.D., Ph.D. - Funding

Ongoing and Completed Projects in the last 3 years

Title: Targeting Ap-1 / ER Crosstalk for the Prevention and Treatment of Breast Cancer

Agency: NIH/NCI R01 CA123246 (Brown)

Role: PI

Period: 06/06/07 - 02/29/12

The major goal of this study is to investiage the importance of crosstalk between the estrogen receptor and AP1 transcription factor in controlling breast cell growth and transformation.

Title: Molecular Mechanism by which Retinoids Prevent Breast Cancer
Agency: NIH/NCI R01 CA78480 (Brown)
Role: PI
Period: 4/1/04-3/31/09
The major goal of this project is to detect the mechanism by which RXR-selective retinoids prevent breast cancer. This is the continuing extension of the preceding grant.

Title: Prevention of ER-Negative Breast Cancer: Identification of Biomarkers Associated with Successful Chemoprevention
Agency: NIH/NCI R01 CA10121 (Brown)
Role: PI
Period: 05/01/03 – 04/30/08
The goal of this project is to identify biomarkers associated with successful chemoprevention of breast cancer using SAGE and proteomic techniques mouse models of ER-negative breast cancer.

Title: U-19 Program Project Chemoprevention of Breast and Ovarian Cancer
Agency: NIH/NCI CA98012 (Brown, Principal Investigator of Program and of Project #3)
Role: PI
Period: 1999-2006
The major goal of Project 3 is to identify promising markers regulated by retinoids in human mammary and ovarian epithelial cells using cDNA microarrays (PI: Brown).

Title: Breast SPORE: Translational Research in Breast Cancer Project 3, “Prevention of Breast Cancer Using Signal Transduction Inhibitors”
Agency: NIH P50 CA58183 (overall SPORE PI: Osborne; Project 3 PI: Brown)
Role: PI
Period: 8/1/02-7/31/07
The major goal of this project is to investigate the mechanisms by which tyrosine kinase inhibitors prevent the development of breast cancer in animals and humans.

Title: Prevention Member of the NSABP
Agency: NIH/NCI U10 CA37377 (Wolmark)
Role: Site PI
Period: 6/1/01-5/31/06
The major goal of this study is to conduct clinical cancer prevention trials through the NSABP cooperative group, including the “STAR Breast Cancer Prevention Trial,” and Phase I and II breast cancer prevention trials.

Title: Neoadjuvant Trial of GW572016 for the Treatment of Women with DCIS Breast Cancer
Agency: Breast Cancer Research Foundation (Brown)
Role: PI
Period: 2004 – 2005
The goal of this project is to conduct a clinical trial testing the dual kinase inhibitor for the treatment of women with DCIS Breast Cancer

Research questions? Contact Dr. Brown by email.