PROFESSIONAL BIOGRAPHY

I graduated from the Department of Plant Pathology at National Taiwan University (Taipei, Taiwan). While I received very little training there in the area of molecular biology, I enjoyed being a "traditional biologist" trekking in the forests to collect specimen. I came to the US in 1984. I went to the graduate program in the Biochemistry Department at SUNY/Buffalo where I received a PhD degree in 1989. My Ph. D. thesis investigated the function of superoxide dismutases (SODs), which remove highly reactive oxygen radicals, generated during the utilization of oxygen in cells. I show that SOD is essential for cell growth when cells are grown aerobically. Mutations in genes encoding SOD have been linked to numerous human diseases such as the Down syndrome and Lou Gehrig's disease. From 1989-1992, I worked as a post-doctoral fellow at Cold Spring Harbor Lab with Michael Wigler, a pioneer in the area of oncogene study, including that of Ras. From 1992-1994, I was promoted to Staff Associate at Cold Spring Harbor Lab. While at the Cold Spring Harbor Lab, I started using S. pombe to study Ras, and I was the first to show that Ras can directly activate Cdc42 by regulating its GEF. From 1995-2001, I started an independent position in the Biology Department at New York University. While at NYU, I continued to explore the function and regulation of Ras and at the same time established a number of important teaching programs (see below). In 2002, I moved to Baylor where I plan to focus on research and to test our ideas based on the yeast data in the mammalian systems.

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Eric Chang, Ph.D.

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