Suzanne Fuqua Laboratory

FUNDING

ACTIVE

Basic Research Award 7/1/07-6/30/09
Susan G. Komen Foundation
Refined Prediction of Hormone Response
The major goal of this project is to determine the contribution of mitogen activated kinase phosphatase 3 to the problem of tamoxifen resistance in breast cancer.

Basic Research Award 7/1/07-6/30/11
Department of Defense
Molecular Classification of Genes Involved in African American Breast Cancer Progression
The major goal of this project is to obtain expression microarray profiles from breast tumors from African American women, and to compare these to profiles from Caucasian women to identify markers associated with aggressive disease

P50 CA58183 (Osborne/Fuqua) 11/30/07-1/30/07
NIH/NCI
SPORE in Breast Cancer Project 4 "Role of Estrogen Receptor α Mutation in Breast Cancer Metastasis"
The major goal of this large Specialized Program of Resource Excellence is to expedite the translation of basic research into applied clinical applications in breast cancer detection, treatment and prevention. This project focuses on the role of an estrogen receptor α mutation in breast cancer metastatic behavior by examining its presence in a large clinical trial comparing an aromatase inhibitor or tamoxifen in patients, and by the use of xenograft and transgenic model systems.

T32 CA90221 (Fuqua) 7/1/02-6/30/07
NIH
Translational Breast Cancer Research Training Program
The major goal of this grant is to provide training opportunities in translational breast cancer research. The training includes laboratory training, interactions with physician scientists, and exposure to clinical breast cancer issues.
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R01 CA72038 (Fuqua) 2/1/03-11/30/08
NIH/NCI
A Hypersensitive ERα Mutant in Breast Cancer Progression
The major goal of this project is to begin to evaluate the potential clinical significance of the K30R ER mutation as an indicator of poor prognosis in primary breast cancer and of more likely progression to invasive cancer.

P01 CA30195 (Osborne/Fuqua) 12/1/03-11/30/08
NIH/NCI
Novel Gene Networks in Breast Development and Cancer Project 1 "Integrating RNA Expression and CGH Profiles to Predict Long-term Breast Cancer Progression"
The major goals of this large Program Project are to identify and characterize the role of novel genetic pathways, which are found to be important in the normal breast, in the pathogenesis and progression of human breast cancer. The major aims of the project are to identify an RNA expression profile that accurately predicts recurrence of node-negative breast cancer, to identify a DNA profile that predicts recurrence of breast cancer, and integrate this profile with RNA expression, and to develop biological models of metastasis-associated gene function to identify critical metastatic signaling pathways.

Basic Research Award 7/1/05-6/30/07
Mary Kay Ash Foundation
DUSP6 and Tamoxifen Resistance
The major aims of the project are to examine the role of the dual specificity phosphatase 6 protein as a biomarker of resistance in human breast cancer.

Basic Research Award
Nancy Owens Memorial Foundation
Ebp50 is a New Key Intermediary in Tamoxifen-Resistant Breast Cancer
The major aim of this project is to determine whether ezrin binding protein Ebp50 is an intermediary in resistance to tamoxifen via signaling to the cytoskeleton.