Adrian Lee Laboratory
FUNDING
Active
R01 CA94118 (Lee) 1/15/02-12/31/06
NIH/NCI
IRS-1 and -2 Signaling in Mammary Development
and Cancer
The goal of this proposal is to examine expression and
regulation of IRS-1and -2 in mammary development, and then test the effect
of reducing or increasing IRS expression on mammary development and carcinogenesis.
R01 CA94118 (Lee) 3/1/04-12/31/06
NIH/NCI
APRC Consortium application ‘Cross-talk between EGFR
and IGF-IR in mammary ductal morphogenesis and the progression to breast
cancer’ - Supplement to IRS-1 and -2 Signaling in Mammary Development
and Cancer
The goal of this proposal is to test if EGF and IGF-I act
synergistically to regulate MEC proliferation and ductal morphogenesis.
P01 CA30195 (Osborne/Lee – Project 3) 4/1/04-3/31/09
NIH/NCI
Novel Gene Networ ks in Breast Development and Cancer,
Project 3: Targeting the Cross-talk Between Serum IGF-1 and Estrogen Pathways
During Breast Tumor Progression
The goal of this proposal is to test whether serum
IGF-I levels are critical for ER-positive mammary gland cancer progression
using mouse models of premalignant disease.
DAMD17-02-1-0286 (Lee) 4/1/02-6/30/05
Department of Defense
A Unique Breast Cancer Cell Model
for Studying Reported Functions of Membrane-Localized Estrogen Receptor α
The goal of this proposal
is to create a breast cancer cell line model that only expresses ER a in
the membrane or cytoplasm and not in the nucleus. This model will then
be used to study membrane or cytoplasmic ER a signaling.
Pilot Project (Lee) 1/1/04-1/1/06
Baylor College of Medicine Cancer Center
Role of the GH/IGF axis in mediating
pregnancy protection from breast cancer
The goal of this proposal is to test whether the reduction in serum
IGF-I levels following pregnancy is responsible for the protection from
subsequent breast cancer.
Chao Scholar Award (Lee) 4/1/04-3/31/06
Baylor College of
Medicine Department of Medicine
Prevention
and treatment of breast cancer using a GH antagonist
The goal of this scholar award is to test whether a GH antagonist can prevent
or block breast cancer growth
R01 CA97213 (Oesterreich) 8/1/02-7/31/07
NIH/NCI
ER Co-Repressor Function of SAFB in Breast Cancer
The goal
of this proposal is to analyze the mechanism of repression as well as the
biological significance of the characterization of SAFB1 as an estrogen
receptor.
R01 DK52197 (Hadsell) 4/1/03-3/31/06
NIH/NIDDK
IGF-I receptor signaling in mammary gland development
The
goal of this proposal is to determine the role of IGF-IR and its downstream
signaling components in mammary gland development.
