Adrian V. Lee, Ph.D. - Publications
The articles are listed in chronological order, with the most recent publications at the top. You can download pdf files of many articles by clicking on the [PDF] text by each listing.
2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | Books/Chapters
2008
Gatza CE, Dumble M, Kittrell F, Edwards DG, Dearth RK, Lee AV, Xu J, Medina D, Donehower LA.Altered mammary gland development in the p53+/m mouse, a model of accelerated aging. Dev Biol. 2008 Jan 1;313(1):130-41. [PDF]
2007
DeNardo DG, Cuba VL, Kim H, Wu K, Lee AV, Brown PH.Estrogen receptor DNA binding is not required for estrogen-induced breast cell growth. Mol Cell Endocrinol. 2007 Oct 15;277(1-2):13-25. [PDF]
Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM.Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev Biol. 2007 Sep 1;309(1):137-49. [PDF]
Hadsell DL, Olea W, Lawrence N, George J, Torres D, Kadowaki T, Lee AV. Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.J Endocrinol. 2007 Aug;194(2):327-36. [PDF]
Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV. Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2.Cell Cycle. 2007 Mar 15;6(6):705-13. [PDF]
Kim HJ, Litzenburger BC, Cui X, Delgado DA, Grabiner BC, Lin X, Lewis MT, Gottardis MM, Wong TW, Attar RM, Carboni JM, Lee AV. Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail. Mol Cell Biol. 2007 Apr;27(8):3165-75. Epub 2007 Feb 12. [PDF]
2006
Maor S, Mayer D, Yarden RI, Lee AV, Sarfstein R, Werner H, Papa MZ. Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1. J Endocrinol. 2006 Dec;191(3):605-12. [PDF]
Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV. Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2. Mol Cell Biol. 2006 Dec;26(24):9302-14. [PDF]
Townson SM, Kang K, Lee AV, Oesterreich S. Novel role of the RET finger protein in estrogen receptor-mediated transcription in MCF-7 cells. Biochem Biophys Res Commun 2006 Oct 20, 349:540-8 [PDF]
Dobrzycka KM, Kang K, Jiang S, Meyer R, Rao PH, Lee AV, Oesterreich S. Disruption of Scaffold Attachment Factor B1 Leads to TBX2 Up-regulation, Lack of p19ARF Induction, Lack of Senescence, and Cell Immortalization. Cancer Res 2006 Aug 15, 66:7859-63 [PDF]
Liao L, Dearth RK, Zhou S, Britton OL, Lee AV, Xu J. Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency. Endocrinology 2006 Aug, 147:3877-88 [PDF]
Schiff R, Lee AV. Can biomarkers direct the optimal use of aromatase inhibitors versus selective estrogen receptor modulators? Nat Clin Pract Oncol 2006 Mar, 3:134-5 [PDF]
Kim HJ, Cui X, Hilsenbeck SG, Lee AV. Progesterone receptor loss correlates with human epidermal growth factor receptor 2 overexpression in estrogen receptor-positive breast cancer. Clin Cancer Res 2006 Feb 1, 12:1013s-1018s [PDF]
Come SE, Buzdar AU, Ingle JN, Arteaga CL, Brown M, Dowsett M, Hilsenbeck SG, Kumar R, Johnston SR, Lee AV, Paik S, Pritchard KI, Winer EP, Hart C. Proceedings of the Fifth International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer: conference summary statement. Clin Cancer Res 2006 Feb 1, 12:997s-1000s [PDF]
Cui X, Kim HJ, Kuiatse I, Kim H, Brown PH, Lee AV. Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH(2)-terminal kinase/activator protein-1 signaling to regulate cell migration. Cancer Res. 2006 May 15;66(10):5304-13. [PDF]
Divisova J, Kuiatse I, Lazard Z, Weiss H, Vreeland F, Hadsell DL, Schiff R, Osborne CK, Lee AV. The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth. Breast Cancer Res Treat. 2006 Mar 16; [Epub ahead of print] [PDF]
2005
Hadsell DL, Torres DT, Lawrence NA, George J, Parlow AF, Lee AV, Fiorotto ML. Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation. Biol Reprod. 2005 Dec;73(6):1116-25. Epub 2005 Aug 3. [Abstract]
Singleton DW, Feng Y, Yang J,
Puga A, Lee AV, Khan SA.Gene expression profiling reveals
novel regulation by bisphenol-A in estrogen receptor-alpha-positive
human cells.
Environ Res. 2006 Jan;100(1):86-92.
2005 Jul 18. [PDF]
Hadsell DL, Torres DT, Lawrence NA, George J, Parlow AF, Lee AV, Fiorotto ML Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation. Biol Reprod. 2005 Dec;73(6):1116-25. 2005 Aug 3. [Abstract]
Reizner N, Maor S, Sarfstein R, Abramovitch S, Welshons WV, Curran EM, Lee AV, Werner H. The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor-alpha and regulates IGF-I receptor gene transcription in breast cancer cells. [Abstract]
Arpino G, Weiss H, Lee AV, Schiff R, De Placido S, Osborne CK, Elledge RM.Estrogen receptor-positive, progesterone
receptor-negative breast cancer: association with growth factor receptor
expression and tamoxifen resistance.
J Natl Cancer Inst. 2005
Sep 7;97(17):1254-61. [PDF]
Cui X, Schiff R, Arpino G, Osborne CK, Lee AV. Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy. J Clin Oncol. 2005 Oct 20;23(30):7721-35. Review. [PDF]
Carboni JM, Lee AV, Hadsell DL, Rowley BR, Lee FY, Bol DK, Camuso AE, Gottardis M, Greer AF, Ho CP, Hurlburt W, Li A, Saulnier M, Velaparthi U, Wang C, Wen ML, Westhouse RA, Wittman M, Zimmermann K, Rupnow BA, Wong TW. Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor. Cancer Res. 2005 May 1;65(9):3781-7. [PDF]
Ivanova M, Dobrzycka KM, Jiang S, Michaelis K, Meyer R, Kang K, Adkins B, Barski OA, Zubairy S, Divisova J, Lee AV, Oesterreich S. Scaffold attachment factor B1 functions in development, growth, and reproduction. Mol Cell Biol. 2005 Apr;25(8):2995-3006. [PDF]
Fuqua SA, Cui Y, Lee AV, Osborne CK, Horwitz KB. Insights into the role of progesterone receptors in breast cancer. J Clin Oncol. 2005 Feb 1;23(4):931-2 [PDF]
2004
Sachdev D, Hartell JS, Lee AV, Zhang X, Yee D. A dominant negative type I insulin-like growth factor-1 receptor inhibits metastasis of human cancer cells. Journal of Biological Chemistry, 279:5017-24, 2004. [PDF]
Fowler AM, Solodin N, Preisler-Mashek MT, Zhang P, Lee AV, Alarid ET. Increases in estrogen receptor- a concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen. FASEB Journal, 18:81-93, 2004. [PDF]
Cui X and Lee AV. Regulatory nodes that integrate and coordinate signaling as potential targets for breast cancer therapy. Clinical Cancer Research, 10:396S-401S, 2004. [PDF]
Kuang SQ, Liao L, Zhang H, Lee AV, O'Malley BW, Xu J. AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Research, 64:1875-85, 2004. [PDF]
Townson SM, Kang K, Lee AV, Oesterreich S. Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: Identification of a potent transcriptional repression domain. Journal of Biological Chemistry, 279:26074-81, 2004. [PDF]
Singleton DW, Feng Y, Chen Y, Busch SJ, Lee AV, Puga A, Khan SA. Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Molecular and Cellular Endocrinology, 221:47-55, 2004. [PDF]
Cui X, Schiff R, Arpino G, Osborne CK, and Lee AV. The Biology of Progesterone Loss in Breast Cancer and its Implications for Endocrine Therapy. In Press.
Lee AV, Chamness G, Oesterreich S. 26th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 3-6 December 2003: update on preclinical and translational research. Breast Cancer Res. 2004 Jan 19;6(2):E10. [PDF]
Lee AV. Location, location, location: regulation of breast cancer progression by the microenvironment. Breast Cancer Res. 2004;6(6):279-80. [PDF]
Come SE, Buzdar AU, Arteaga CL, Bissell MJ, Brown MA, Ellis MJ, Goss PE, Green JE, Ingle JN, Lee AV, Medina D, Nicholson RI, Santen RJ, Schiff R, Hart CS. Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement. Clin Cancer Res. 2004 Jan 1;10(1 Pt 2):327S-330S. [PDF]
2003
Lee AV , Taylor ST , Greenall J, Mills JD, Tonge DW, Zhang P, George J, Fiorotto ML, and Hadsell D. Rapid induction of IGF-IR signaling in normal and tumor tissue following intravenous injection of IGF-I in mice. Hormone and Metabolic Research, 35:651-5, 2003. [PDF]
Sachdev D, Hartell JS, Lee AV, Zhang X, Yee D. A Dominant Negative Type I Insulin-like Growth Factor-1 Receptor Inhibits Metastasis of Human Cancer Cells. In press. Journal of Biological Chemistry, 2003. [PDF]
Cui X, Lazard Z, Zhang P, Hopp T, Oesterreich S, Lee AV. Progesterone Potentiates Insulin Receptor Substrate 2 Signals in Breast Cancer Cells. In press. Oncogene 2003. [PDF]
Lee AV, Cui X, Deng W, Ivanova M, Hadsell D, Behrens J, Oesterreich S. Estrogen-mediated Downregulation of E-Cadherin in Breast Cancer Cells. Under revision. Cancer Research, 2003. [PDF]
Farrell F, Paik S, Lee AV. The Erythropoietin Receptor and Its Expression in Tumor Cells and Other Tissues. Oncologist. 2004;9 Suppl 5:18-30. [PDF]
Lee AV, Zhang P, Ivanova M, Bonnette S, Oesterreich S, Rosen JM, Grimm S, Hovey RC, Vonderhaar BK, Kahn CR ,Torres D, George J, Mohsin S, Allred DC, and Hadsell DL. Developmental and Hormonal Signals Dramatically alter the Localization and Abundance of Insulin Receptor Substrate Proteins in the Mammary Gland. Endocrinology, 144: 2683-94, 2003. [PDF]
Townson S, Deng W, Dobrzycka KM, Air M, Lee AV, Kang K, Jiang S, Michaelis K, Oesterreich S. SAFB2- A New SAFB Homolog and Estrogen Receptor Corepressor. Journal of Biological Chemistry. 278: 20059-68, 2003. [PDF]
Cui X, Zhang P, Deng W, Oesterreich S, Lu Y, Mills GB, and Lee AV. IGF-I Inhibits Progesterone Receptor Expression in Breast Cancer Cells via the PI3K/Akt/mTOR Pathway: Progesterone Receptor as a Potential Indicator of Growth Factor Activity in Breast Cancer. Molecular Endocrinology, 17: 575-588, 2003. [PDF]
Come SE, Buzdar AU, Arteaga CL, Brodie A, Davidson N, Dowsett M, Ingle JN, Johnston SRD, Lee AV, Osborne CK, Pritchard KI, Vogel VG, Miner EP, Hart C. Proceedings of the Second International Conference on Recent Advances and Future Directions in Endocrine. Therapy for Breast Cancer: Summary Consensus Statement. Clinical Cancer Research, 9: 443S-6S, 2003 [PDF]
Hovey RC, Harris J, Hadsell DL, Lee AV, Ormandy CJ, Vonderhaar BK. Local insulin-like growth factor-II mediates prolactin-induced mammary gland development. Molecular Endocrinology, 17: 460-71, 2003. [PDF]
Lee AV, Schiff R, Cui X, Sachdev D, Yee D, Gilmore A, Streuli C, Oesterreich S, and Hadsell DL. New mechanisms of signal transduction inhibitor action: Receptor tyrosine kinase down-regulation and blockade of signal transactivation. Clinical Cancer Research, 9: 516S-23S, 2003. [PDF]
2002
Grimm S, Seagroves T, Kabotyanski E, Hovey R, Vonderhaar BK, Lydon JP, Miyoshi K, Henrighausen L, Ormandy CJ, Lee AV, Stull M, Wood, TA, Rosen JM. Disruption of Steroid and Prolactin Receptor Patterning in the Mammary Gland Correlates With a Block in Lobuloalveolar Development. Molecular Endocrinology, 16: 2675-91, 2002. [PDF]
Hadsell D, Bonnette S and Lee AV. Genetic manipulation of the IGF-I axis to regulate mammary gland development and function. Journal of Dairy Science 85: 1-13, 2002. [PDF]
2001
Buzdar AU, Come SE, Brodie A, Ellis M, Goss PE, Ingle JN, Johnston SRD, Lee AV, Osborne CK, Vogel VG, Hart C. Proceedings of the first international conference on recent advances and future directions in endocrine therpay for breast cancer: Summary concensus statement. Clinical Cancer Research 7: 1s-6s, 2001.
Thordarson G, Lee AV, McCarty M, Van Horn K, Chu O, Chou Y, Yang J, Guzman R, Nandi S, Talamates F. Growth and characterization of N-methyl-N-nitrosourea-induced mammary tumors in intact and ovariectomized animals. Carcinogenesis 22: 2039-2047, 2001. [PDF]
Lee AV, Cui X and Oesterreich S: Cross talk among estrogen receptor, epidermal growth factor, and insulin-like growth factors in human breast cancer. Clinical Cancer Research 7:4429s-4435s, 2001.
Oesterreich S, Zhang P, Guler RL, Sun X, Curran EM, Welshons WV, Osborne CK, Lee AV: Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth. Cancer Research 61: 5771-5777, 2001. [PDF]
Feliers D, Duch J, Stewart JL, Lee AV, Abboud HE, Ghosh-Choudhury G, Kasinath BS: Activation of signaling pathways in the renal cortex of db/db mice with type 2 diabetes. Kidney International 60:495-504, 2001 [PDF]
Hadsell DL, Alexeenko T, Klemintidis Y, Torres D, Lee AV: Inability of overexpressed des (1-3) IGF-I to inhibit forced mammary gland involution is associated with decreased expression of IGF signaling molecules. Endocrinology 142: 1479-1488, 2001 [PDF]
Oesterreich S, Allred DC, Lee AV, Osborne CK, O’Connell P: Loss of heterozygosity at the HET/SAF-B locus (19p13) in human breast cancer. British Journal of Cancer 84:1-6, 2001. [Abstract]
2000
Lee AV, Guler BL, Sun X, Oesterreich S, Zhang QP, Curran EM, Welshons WV: Oestrogen receptor is a critical component required for insulin-like growth factor (IGF)-mediated signaling and growth in MCF-7 cells. European Journal of Cancer 36S4:109-110, 2000. [PDF]
Oesterreich S, Zhang QP, Lee AV: Inhibition of oestrogen receptor activity by the co-repressor HET/SAF-B is relieved by blockade of histone deacetylase activity. European Journal of Cancer 36 S4:43-4, 2000. [PDF]
Townson S, Sullivan T, Zhang QP, Yee D, Clark GM, Osborne CK, Lee AV, Oesterreich S: HET/SAF-B overexpression causes growth arrest and multinuclearity and is associated with aneuploidy in human breast cancer. Clinical Cancer Research 6:3788-96, 2000. [PDF]
Lee AV and Yee D: Cross talk between the insulin-like growth factors and estrogens. Journal of Mammary Gland Biology and Neoplasia 5:107-115, 2000. [PDF]
Oesterreich S, Zhang Q, Hopp T, Fuqua SAW, Michaelis M, Dallas S, Yang L, Brown P, Zhao H, Davie JR, Mohsin S, Allred DC, Osborne CK, Lee AV: Estrogen receptor bound to the antiestrogen tamoxifen strongly interacts with the nuclear matrix protein HET/SAF-B, a novel inhibitor of estrogen receptor-mediated transactivation. Molecular Endocrinology 14:369-381, 2000 [PDF]
Lee AV, Gooch JL, Oesterreich S, Guler B, Yee D: IGF-I induced degradation of insulin receptor substrate-1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition. Molecular and Cellular Biology 20:1489-1496, 2000. [PDF]
1999
Lee AV, Jackson JG, Gooch JL, Hilsenbeck SG, Osborne CK, Yee D: Enhancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of IRS-1 expression in vitro and in vivo. Molecular Endocrinology 13:787-796, 1999. [PDF]
Books/Chapters:
Townson S, Ivanova M, Lee AV, Oesterreich S. The Role of Estrogen in Normal Breast Development and Breast Cancer. In Natural and Synthetic Estrogens: Aspects of the Cellular and Molecular Activity, Dopp E. (ed), Research Signpost, Kerala, India, pp 33-55, 2002.
Yee D and Lee AV: Insulin-like growth factors and endocrine neoplasia. In Contemporary Endocrinology: Endocrine Oncology, Ethier, S.P. (ed), Humana Press Inc., Totowa, NJ, pp 193-214, 2000.
Lee AV, Yee D. The IGF system in breast cancer cell proliferation and progression. In Endocrinology of Breast Cancer, Manni A (ed), Humana Press, Totowa, NJ, 1999, pp 187-204.
Yee D, Jackson JG, Weng C-N, Gooch JL, Lee AV. The IGF system in breast cancer. In Molecular Mechanisms to Regulate the Activities of Insulin-like Growth Factors (Excerpta Medica International Congress Series 1151), Takano K, Hizuka N, Takahashi S-I (eds), Elsevier Science BV, Amsterdam, pp 319-325, 1998.
Lee AV, Oesterreich S and Fuqua SAW: Estrogen receptor variants in early breast disease and breast cancer progression. Advances in Oncology – Breast Cancer, Heppner GH, Visscher DW and Peters WP (eds) J A I Press Inc, 1998.
