Steffi Oesterreich Laboratory
FUNDING
Ongoing Research Support
R01 CA97213 (Oesterreich) 8/1/02-7/31/07
NIH/NCI
ER Co-Repressor Function of SAFB in Breast Cancer
The major goal of this
project is to define the mechanism of repression and the biological significance
of the estrogen receptor corepressor SAFB.
P01 CA30195 (Osborne/Oesterreich) 4/1/04-3/31/09
NIH/NCI
Novel Gene Networks in Breast Development and Cancer
Project 2 - "Scaffold
Attachment Factors SAFB1/2 as Novel Breast Tumor Suppressor Genes"
The
major goals of this large Program Project are to identify and characterize
the role of novel genetic pathways, which are found to be important in
the normal breast, in the pathogenesis and progression of human breast
cancer. Dr. Oesterreich's specific project deals with the characterization
of SAFB1 and SAFB2 as tumor suppressor genes, mainly through identification
of mechanism(s) of inactivation, and generation and analysis of knockout
mouse models.
W81XWH-04-1-0423 (Oesterreich) 3/15/04-3/14/07
Department of Defense
The Scaffold Attachment Factor SAFB1: A new player
in G2/M checkpoint control?
The major goal of this project is to prove
that SAFB1 is critical in G2/M checkpoint control and in resistance to G2/M
blockers.
DAMD17-02-1-0286 (Lee) 4/1/02-3/31/05
DOD
A Unique Breast Cancer Cell Model for Studying Reported Functions of
Membrane-localized Estrogen Receptor a
The major goal of this project is
to create a unique and novel breast cancer cell line model that only expresses
ER a in the membrane or cytoplasm and not in the nucleus. This model will
then be used to study membrane or cytoplasmic ER a signaling.
Research Completed in the Last 3 Years
K01 CA77674-01(Oesterreich) 6/1/98-5/31/03
NIH/NCI
Temin Award: A New Nuclear Matrix Protein in Breast Cancer Growth
The major
goal of this project is to determine the role of HET (hsp27-ERE-TATA binding
protein) in proliferation of breast cancer cells.
BC971976 (Oesterreich) 9/30/98-9/29/01
DOD
IDEA Award: HET is a Novel Tumor Suppressor Gene in Human Breast Cancer
The
major goal of this project is to determine whether HET is the tumor suppressor
gene at 19p13 by doing LOH studies using additional markers, and by sequencing
HET. We also propose to demonstrate that the neoplastic phenotype in breast
cancer cells harboring HET mutations can be reversed by introduction of wildtype
but not mutated HET.
None (Oesterreich) 7/1/00-6/30/03
BCM Dept of Med
CHAO Award: Is HET/SAF-B a tumor suppressor gene in breast
cancer? Generation of a mouse model.
This grant is an institutional award.
The major goal of this project is to generate a HET/SAF-B null mouse by gene
targeting.
