Sample Size Calculation/Study Design for Clinical Trials

Links

Description

http://biostats.upci.pitt.edu/biostats/
ClinicalStudyDesign/

Applets and lectures on design of phase I and II clinical trials. Developed by Univ. of Pittsburgh Cancer Institute Biostatistics Facility.

http://biostatistics.mdanderson.org/
SoftwareDownload/SingleSoftware.aspx?
Software_Id=1

Program to implement Continual Reassessment Method for dose-finding in phase I trials. Developed by Department of Biostatistics, MD Anderson Cancer Center.

http://www.cancerbiostats.onc.jhmi.edu/
software.cfm

Programs for blocked randomization, power and sample size for clinical trials, CRM for phase I trials, and optimal design for phase II trials. Developed by Division of Biostatistics at Johns Hopkins.

http://hedwig.mgh.harvard.edu/
sample_size/size.html

Sample size and power calculations for binary, continuous, and time to event outcomes in a two-group comparative setting. Developed by Dr. David Schoenfeld at Massachusetts General Hospital GCRC.

http://www.stat.uiowa.edu/~rlenth/
Power/index.html

Java applets for power and sample size calculation. includes programs for various statistical methods (one and two group comparisons, linear regression, ANOVA) developed by Russ Lenth from Univ of Iowa.

http://linus.nci.nih.gov/~brb/
Methodologic.htm  

Splus program for Accelerated Titration Designs for phase I trials. Developed by Biometric Research Branch, NCI.

http://biostatistics.mdanderson.org/
SoftwareDownload/SingleSoftware.aspx
?Software_Id=2

Program for dose-finding and safety monitoring based on efficacy and adverse outcomes in phase I/II clinical trials. Developed by Department of Biostatistics, MD Anderson Cancer Center.